" ...We investigated whether the diverse experimental evidence can be unified by creating a spatial, mechanistic model of multiple signaling pathways in hippocampal CA1 neurons. Our results show that the combination of activity of several key kinases can predict the occurrence of long-lasting forms of LTP for multiple experimental protocols. ..."
Model Type: Synapse
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Simulation Environment: NeuroRD
Jȩdrzejewska-Szmek J, Luczak V, Abel T, Blackwell KT. (2017). ß-adrenergic signaling broadly contributes to LTP induction. PLoS computational biology. 13 [PubMed]