ffian is an implementation of the KNP continuity equations for a one-dimensional system containing two compartments: one representing an astrocyte network (ICS) and one representing the extracellular space (ECS). ffian.The model takes both transmembrane- and compartmental fluid flow into account and predicts the evolution in time and distribution in space of the volume fractions, ion concentrations (Na+, K+, Cl-), electrical potentials, and hydrostatic pressures in the ICS and ECS. Example simulations and installation guidelines can be found here: https://github.com/martejulie/fluid-flow-in-astrocyte-networks
Model Type: Glia; Extracellular
Currents: Kir; Na/K pump; I Cl, leak; I Na, leak
Model Concept(s): Cellular volume dynamics; Potassium buffering; Electrodiffusion; Homeostasis; Electrical-chemical
Simulation Environment: Python
References:
Sætra MJ, Ellingsrud AJ, Rognes ME. (2023). Neural activity induces strongly coupled electro-chemo-mechanical interactions and fluid flow in astrocyte networks and extracellular space-A computational study. PLoS computational biology. 19 [PubMed]