Simulation of ectopic burst firings from distal axons induced by local inhibition of axonal K channels on the hippocampal mossy fibers.
Experimental motivation: To test for possible ectopic spiking at the distal axon by application of a K channel blocker, a well-known condition causing hyperexcitability of the hippocampal network.
Model Type: Axon
Region(s) or Organism(s): Hippocampus
Cell Type(s): Dentate gyrus granule GLU cell
Receptors:
Genes:
Transmitters:
Model Concept(s): Action Potentials; Axonal Action Potentials; Excitability
Simulation Environment: NEURON
Implementer(s): Kamiya, Haruyuki [kamiya at med.hokudai.ac.jp]
References: