Axonal K channel inhibition promotes ectopic burst of hippocampal mossy fiber (Kamiya 2024)

Simulation of ectopic burst firings from distal axons induced by local inhibition of axonal K channels on the hippocampal mossy fibers.

Experimental motivation: To test for possible ectopic spiking at the distal axon by application of a K channel blocker, a well-known condition causing hyperexcitability of the hippocampal network.

Model Type: Axon

Region(s) or Organism(s): Hippocampus

Cell Type(s): Dentate gyrus granule GLU cell

Currents: I K; I Na,t




Model Concept(s): Action Potentials; Axonal Action Potentials; Excitability

Simulation Environment: NEURON

Implementer(s): Kamiya, Haruyuki [kamiya at]


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