Based on the Layer 5 thick-tufted pyramidal cell from the Blue Brain Project, we modeled the selective block of Nav1.2 and Nav1.6 to determine their precise roles in pyramidal cell excitability.
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Prefrontal cortex (PFC)
Cell Type(s):
Currents:
Receptors:
Genes: Nav1.2 SCN2A; Nav1.6 SCN8A
Transmitters:
Model Concept(s):
Simulation Environment: NEURON; Python
References: