Differential roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability (Garcia et al. 2025)


Based on the Layer 5 thick-tufted pyramidal cell from the Blue Brain Project, we modeled the selective block of Nav1.2 and Nav1.6 to determine their precise roles in pyramidal cell excitability.

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Prefrontal cortex (PFC)

Cell Type(s):

Currents:

Receptors:

Genes: Nav1.2 SCN2A; Nav1.6 SCN8A

Transmitters:

Model Concept(s):

Simulation Environment: NEURON; Python

References:


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