Here we use cohorts of biophysically detailed, multicompartmental models of rhesus monkey dorsolateral prefrontal cortex (dlPFC) layer 3 pyramidal neurons to investigate how axon collateralization, myelin dystrophy, and other structural and biophysical perturbations affect AP conduction velocity (CV).
Experimental motivation: Axon collaterals extend a given neuron's range by distributing signals to multiple targets, but they also introduce increased current demands. Myelination facilitates saltatory conduction, dramatically enhancing transmission speed and ensuring conduction fidelity over long distances. The interplay between myelin dystrophy and axonal arborization remains largely unexplored, despite their role in the impairment of AP conduction in brain circuits.
Model Type: Axon; Neuron or other electrically excitable cell
Region(s) or Organism(s): Prefrontal cortex (PFC)
Cell Type(s): Myelinated neuron
Currents:
Receptors:
Genes:
Transmitters:
Model Concept(s): Action Potentials; Conduction failure
Simulation Environment: NEURON
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