BDNF morphological contributions to AP enhancement (Galati et al. 2016)

" ... We quantified BDNF’s effect on cultured cortical neuron morphological parameters and found that BDNF stimulates dendrite growth and addition of dendrites while increasing both excitatory and inhibitory presynaptic inputs in a spatially restricted manner. To gain insight into how these combined changes in neuron structure and synaptic input impact AP generation, we used the morphological parameters we gathered to generate computational models. Simulations suggest that BDNF-induced neuron morphologies generate more APs under a wide variety of conditions. ..."

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Neocortex dissociated cultured nerve cell

Currents: I Na,t; I K

Model Concept(s): Action Potentials; Active Dendrites; Development

Simulation Environment: NEURON (web link to model)

Implementer(s): Galati, Domenico F


Galati DF, Hiester BG, Jones KR. (2016). Computer Simulations Support a Morphological Contribution to BDNF Enhancement of Action Potential Generation. Frontiers in cellular neuroscience. 10 [PubMed]

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