High entrainment constrains synaptic depression in a globular bushy cell (Rudnicki & Hemmert 2017)

" ... Here we show how different levels of synaptic depression shape firing properties of GBCs in in vivo-like conditions using computer simulations. We analyzed how an interplay of synaptic depression (0 % to 70 %) and the number of auditory nerve fiber inputs (10 to 70) contributes to the variability of the experimental data from previous studies. ... Overall, this study helps to understand how synaptic properties shape temporal processing in the auditory system. It also integrates, compares, and reconciles results of various experimental studies."

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Auditory brainstem

Cell Type(s): Cochlear nucleus bushy GLU cell; Auditory nerve

Model Concept(s): Depression; Short-term Synaptic Plasticity; Spike Frequency Adaptation; Audition

Simulation Environment: Brian (web link to method); NEURON (web link to model); Python (web link to model)

Implementer(s): Rudnicki, Marek [marek.rudnicki at tum.de]


Rudnicki M, Hemmert W. (2017). High Entrainment Constrains Synaptic Depression Levels of an In vivo Globular Bushy Cell Model. Frontiers in computational neuroscience. 11 [PubMed]

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