CRH modulates excitatory transmission and network physiology in hippocampus (Gunn et al. 2017)

This model simulates the effects of CRH on sharp waves in a rat CA1/CA3 model. It uses the frequency of the sharp waves as an output of the network.

Model Type: Connectionist Network

Region(s) or Organism(s): Hippocampus

Cell Type(s): Abstract Wang-Buzsaki neuron; Pinsky-Rinzel CA1/3 pyramidal cell

Transmitters: Glutamate; Gaba

Model Concept(s): Brain Rhythms

Simulation Environment: Brian; Python

Implementer(s): Cox, Conor [cdcox1 at gmail.com]

References:

Taxidis J, Coombes S, Mason R, Owen MR. (2012). Modeling sharp wave-ripple complexes through a CA3-CA1 network model with chemical synapses. Hippocampus. 22 [PubMed]

Gunn BG et al. (2017). The Endogenous Stress Hormone CRH Modulates Excitatory Transmission and Network Physiology in Hippocampus. Cerebral cortex (New York, N.Y. : 1991). 27 [PubMed]