Cav1.3 channels in motoneuron dendrites are actively involved during normal motor activities. To investigate the effects of the activation of motoneuron Cav1.3 channels on force production, a model motor unit was built based on best-available data. The simulation results suggest that force potentiation induced by Cav1.3 channel activation is strongly modulated not only by firing history of the motoneuron but also by length variation of the muscle as well as neuromodulation inputs from the brainstem.
Model Type: Neuron or other electrically excitable cell
Genes: Cav1.3 CACNA1D
Model Concept(s): Active Dendrites
Simulation Environment: NEURON
Implementer(s): Kim, Hojeong [hojeong.kim03 at gmail.com]
Kim H. (2017). Muscle length-dependent contribution of motoneuron Cav1.3 channels to force production in model slow motor unit. Journal of applied physiology (Bethesda, Md. : 1985). 123 [PubMed]