The role of glutamate in neuronal ion homeostasis: spreading depolarization (Hubel et al 2017)

This model includes ion concentration dynamics (sodium, potassium, chloride) inside and outside the neuron, the exchange of ions with glia and blood vessels, volume dynamics of neuron, glia, and extracellular space, glutamate homeostasis involving release by neuron and uptake by both neuron and glia. Spreading depolarization is used as a case study.

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Generic; Neocortex

Cell Type(s): Astrocyte

Currents: I Potassium; I Sodium; I Cl, leak; I K,leak; I Na, leak; Na/K pump

Receptors: AMPA; Glutamate

Transmitters: Glutamate

Model Concept(s): Action Potentials; Homeostasis

Simulation Environment: XPPAUT

Implementer(s): Ullah, Ghanim [ghanim.phy at]; Hubel, Niklas


Hübel N, Hosseini-Zare MS, Žiburkus J, Ullah G. (2017). The role of glutamate in neuronal ion homeostasis: A case study of spreading depolarization. PLoS computational biology. 13 [PubMed]

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