"There have been few quantitative characterizations of the morphological, biophysical, and cable properties of neurons in the human neocortex. We employed feature-based statistical methods on a rare data set of 60 3D reconstructed pyramidal neurons from L2 and L3 in the human temporal cortex (HL2/L3 PCs) removed after brain surgery. Of these cells, 25 neurons were also characterized physiologically. Thirty-two morphological features were analyzed (e.g., dendritic surface area, 36 333 ± 18 157 µm2; number of basal trees, 5.55 ± 1.47; dendritic diameter, 0.76 ± 0.28 µm). ... A novel descriptor for apical dendritic topology yielded 2 distinct classes, termed hereby as “slim-tufted” and “profuse-tufted” HL2/L3 PCs; the latter class tends to fire at higher rates. Thus, our morpho-electrotonic analysis shows 2 distinct classes of HL2/L3 PCs."
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Neocortex
Model Concept(s): Electrotonus
Simulation Environment: NEURON
Implementer(s): Eyal, Guy [guy.eyal at mail.huji.ac.il]; Deitcher, Yair [yair.deitcher at mail.huji.ac.il]
References:
Deitcher Y et al. (2017). Comprehensive Morpho-Electrotonic Analysis Shows 2 Distinct Classes of L2 and L3 Pyramidal Neurons in Human Temporal Cortex. Cerebral cortex (New York, N.Y. : 1991). 27 [PubMed]