"... In postanoxic coma, EEG patterns indicate the severity of encephalopathy and typically evolve in time. We aim to improve the understanding of pathophysiological mechanisms underlying these EEG abnormalities. ... We used a mean field model comprising excitatory and inhibitory neurons, local synaptic connections, and input from thalamic afferents. Anoxic damage is modeled as aggravated short-term synaptic depression, with gradual recovery over many hours. Additionally, excitatory neurotransmission is potentiated, scaling with the severity of anoxic encephalopathy. Simulations were compared with continuous EEG recordings of 155 comatose patients after cardiac arrest. ..."
Region(s) or Organism(s): Thalamus
Simulation Environment: MATLAB (web link to model)
Implementer(s): Ruijter, Barry J [b.j.ruijter at utwente.nl]
Ruijter BJ, Hofmeijer J, Meijer HGE, van Putten MJAM. (2017). Synaptic damage underlies EEG abnormalities in postanoxic encephalopathy: A computational study. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 128 [PubMed]