"The balance between excitatory and inhibitory inputs is a key feature of cortical dynamics. Such a balance is arguably preserved in dendritic branches, yet its underlying mechanism and functional roles remain unknown. In this study, we developed computational models of heterosynaptic spike-timing-dependent plasticity (STDP) to show that the excitatory/inhibitory balance in dendritic branches is robustly achieved through heterosynaptic interactions between excitatory and inhibitory synapses. The model reproduces key features of experimental heterosynaptic STDP well, and provides analytical insights. ..."
Model Type: Synapse
Simulation Environment: Python (web link to model)
Implementer(s): Hiratani,Naoki [N.Hiratani at gmail.com]
Hiratani N, Fukai T. (2017). Detailed Dendritic Excitatory/Inhibitory Balance through Heterosynaptic Spike-Timing-Dependent Plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 37 [PubMed]