Here we develop an integrated neuromechanical model of the ENS and assess neurostimulation strategies for enhancing gut motility. The model includes a network of enteric neurons, smooth muscle fibers, and interstitial cells of Cajal, which regulate propulsion of a virtual pellet in a model of gut motility.
Model Type: Extracellular; Neuron or other electrically excitable cell
Region(s) or Organism(s): Enteric nervous system
Simulation Environment: Brian 2; Python
Implementer(s): Barth, Bradley [bradley.barth at duke.edu]
References:
Barth BB, Henriquez CS, Grill WM, Shen X. (2017). Electrical stimulation of gut motility guided by an in silico model. Journal of neural engineering. 14 [PubMed]