Control of oscillations and spontaneous firing in dopamine neurons (Rumbell & Kozloski 2019)

Model of Substantia Nigra pars Compacta Dopamine Neuron. 'Toy' morphology with 4 dendrites, one of which is the axon-bearing dendrite, with an axon branching from it. The axon is a short 'axon initial segment' compartment, followed by a longer 'axon'. 727 parameter sets for ion channel conductance and kinetic parameters were found using evolutionary optimization, all of which are viable candidates representing a plausible model of a SNc DA.

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Basal ganglia

Cell Type(s): Substantia nigra pars compacta DA cell

Currents: I A; I Calcium; I h; I K; I K,Ca; I Na,t

Model Concept(s): Pacemaking mechanism; Parameter Fitting; Parameter sensitivity

Simulation Environment: NEURON

Implementer(s): Rumbell, Tim [timrumbell at]


Rumbell T, Kozloski J. (2019). Dimensions of control for subthreshold oscillations and spontaneous firing in dopamine neurons PLOS Computational Biology. 15

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