"...We studied pyramidal neurons and two classes of GABAergic interneurons of layer 5 in neocortical brain slices obtained from rats of both sexes, and we stimulated them with biophysically realistic correlated inputs, generated using dynamic clamp. We found that the physiological differences between cell types manifested unique features in their capacity to transfer correlated inputs. We used linear response theory and computational modeling to gain clear insights into how cellular properties determine both the gain and timescale of correlation transfer, thus tying single-cell features with network interactions. Our results provide further ground for the functionally distinct roles played by various types of neuronal cells in the cortical microcircuit..."
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Neocortex
Simulation Environment: MATLAB
Implementer(s): Ocker, Gabriel K
Linaro D, Ocker GK, Doiron B, Giugliano M. (2019). Correlation Transfer by Layer 5 Cortical Neurons Under Recreated Synaptic Inputs In Vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience. 39 [PubMed]