A computational model of a small DRG neuron to explore pain (Verma et al. 2019, 2020)

This is a Hodgkin-Huxley type model for a small DRG neuron consisting of four voltage-gated ion channels: sodium channels 1.7 and 1.8, delayed rectifier potassium, and A-type transient potassium channels. This model was used to explore the dynamics of this neuron using bifurcation theory, with the motive to investigate pain since small DRG neuron is a pain-sensing neuron.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Dorsal Root Ganglion (DRG) cell

Currents: I Sodium; I Potassium

Genes: Nav1.7 SCN9A; Nav1.8 SCN10A

Model Concept(s): Action Potentials; Bifurcation

Simulation Environment: MATLAB; XPPAUT

Implementer(s): Verma, Parul [parulv.iitb at gmail.com]


Verma P, Kienle A, Flockerzi D, Ramkrishna D. (2020). Using Bifurcation Theory for Exploring Pain Industrial & Engineering Chemistry Research. 59

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