We implemented the single-compartment model of vagal afferents from Schild et al. 1994 and extended the model into a multi-compartment axon, presenting the first C-fiber cable model of a C-fiber vagal afferent. We also implemented the updated parameters from Schild and Kunze 1997. We compared the responses of these novel models to three published models of unmyelinated axons (Rattay and Aberham 1993; Sundt et al. 2015; Tigerholm et al. 2014).
Simulation Environment: NEURON; Brian 2; MATLAB
References:
Pelot NA et al. (2021). Excitation Properties of Computational Models of Unmyelinated Peripheral Axons Journal of neurophysiology. 125 [PubMed]