Entrainment and divisive inhibition in a neocortical neural mass model (Papasavvas et al 2020)

Neural mass model of a neocortical microcircuit featuring one excitatory and two inhibitory populations. The inhibitory populations represent the soma-targeting (parvalbumin) and dendrite-targeting (somatostatin) interneurons. The model uses the Wilson-Cowan formalism and differentiates between the two inhibitory populations by the way they modulate the input-output function of the excitatory population (subtractive vs divisive inhibition, based on Wilson et al., Nature, 7411, 488, 343-348, 2012). The connectivity patterns between the populations follow the patterns reported in the primary visual cortex (Pfeffer et al., Nat Neurosci 16, 1068–1076, 2013). The model is used here to investigate the role of divisive inhibition during the entrainment of the microcircuit.

Model Type: Neural mass

Region(s) or Organism(s): Neocortex

Model Concept(s): Contrast-gain control; Oscillations

Simulation Environment: MATLAB

Implementer(s): Papasavvas, Christoforos [Christoforos.Papasavvas at newcastle.ac.uk]


Papasavvas CA, Trevelyan AJ, Kaiser M, Wang Y. (2020). Divisive gain modulation enables flexible and rapid entrainment in a neocortical microcircuit model. Journal of neurophysiology. 123 [PubMed]

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