A model of closed-loop motor unit including muscle spindle feedback (Kim, 2020)

Persistent inward current generating ion channels are located over spinal motoneurons and actively recruited during normal behaviors. Constructing a realistic computational model of closed-loop motor unit, a motoneuron and muscle fibers that it innervates including muscle spindle afferents, the study reveals functional linkage between persistent inward current location, motoneuron discharge pattern and muscle force output at various muscle lengths. This systematic analysis may provide useful insights into interplay of spinal and muscular mechanisms in control of movements.

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Spinal motoneuron

Currents: I Calcium; I Potassium; I Sodium; I_AHP

Genes: Cav1.3 CACNA1D

Model Concept(s): Motor control

Simulation Environment: NEURON

Implementer(s): Kim, Hojeong [hojeong.kim03 at gmail.com]


Kim H. (2020). Linking Motoneuron PIC Location to Motor Function in Closed-Loop Motor Unit System Including Afferent Feedback: A Computational Investigation. eNeuro. 7 [PubMed]

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