Persistent inward current generating ion channels are located over spinal motoneurons and actively recruited during normal behaviors. Constructing a realistic computational model of closed-loop motor unit, a motoneuron and muscle fibers that it innervates including muscle spindle afferents, the study reveals functional linkage between persistent inward current location, motoneuron discharge pattern and muscle force output at various muscle lengths. This systematic analysis may provide useful insights into interplay of spinal and muscular mechanisms in control of movements.
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Spinal motoneuron
Genes: Cav1.3 CACNA1D
Model Concept(s): Motor control
Simulation Environment: NEURON
Implementer(s): Kim, Hojeong [hojeong.kim03 at gmail.com]