We simulated chirp current stimulation in the apical dendrites of 5 biophysically-detailed multi-compartment models of neocortical pyramidal tract neurons and found that a combination of HCN channels and TASK-like channels produced the best fit to experimental measurements of dendritic impedance. We then explored how HCN and TASK-like channels can shape the dendritic impedance as well as the voltage response to synaptic currents.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex M1 L5B pyramidal pyramidal tract GLU cell
Currents: I h; TASK channel
Model Concept(s): Impedance
Simulation Environment: NEURON; Python; NetPyNE
Implementer(s): Kelley, Craig
References:
Kelley C et al. (2021). Effects of Ih and TASK-like shunting current on dendritic impedance in layer 5 pyramidal-tract neurons. Journal of neurophysiology. 125 [PubMed]