We fit a simplified Luo-Rudy model to voltage-clamp data showing a circadian rhythm in L-type calcium conductance. Simulations of the model (single-cell and 2-D spatial versions) suggest that circadian rhythms in early afterdepolarizations may contribute to daily rhythms in cardiac arrhythmias and sudden cardiac death.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Cardiac ventricular cell
Simulation Environment: MATLAB
Implementer(s): Diekman, Casey O. [casey.o.diekman at njit.edu]