Grid cell-to-place cell transformation model w AD-related synaptic loss (Ness and Schultz 2021)

Simulation of grid-cell-to-place cell transformation with interneuron-mediated feedback inhibition, BCM learning and synaptic turnover. Generates place cell activity with stable place cell density over time. Excitatory synapse and/or inhibitory synapse loss can be implemented to analyse the effect of synaptic loss on place cell function.

Cell Type(s): Hippocampus CA1 pyramidal GLU cell

Simulation Environment: Python


Ness N, Schultz SR. (2021). A computational grid-to-place-cell transformation model indicates a synaptic driver of place cell impairment in early-stage Alzheimer's Disease. PLoS computational biology. 17 [PubMed]

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