Simulation of grid-cell-to-place cell transformation with interneuron-mediated feedback inhibition, BCM learning and synaptic turnover. Generates place cell activity with stable place cell density over time. Excitatory synapse and/or inhibitory synapse loss can be implemented to analyse the effect of synaptic loss on place cell function.
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Simulation Environment: Python
Ness N, Schultz SR. (2021). A computational grid-to-place-cell transformation model indicates a synaptic driver of place cell impairment in early-stage Alzheimer's Disease. PLoS computational biology. 17 [PubMed]