In this models we investigated how the threshold eGABA, at which GABAergic inhibition switches to excitation, depends on the spatiotemporal constrains in a ball-and-stick neurons and a neurons with a topology derived from an reconstructed neuron.
Model Type: Synapse; Neuron or other electrically excitable cell
Region(s) or Organism(s): Hippocampus
Cell Type(s): Hippocampus CA3 pyramidal GLU cell
Model Concept(s): Development; Action Potentials
Simulation Environment: NEURON
Implementer(s): Kilb, Werner [wkilb at uni-mainz.de]
References:
Lombardi A, Luhmann HJ, Kilb W. (2021). Modelling the spatial and temporal constrains of the GABAergic influence on neuronal excitability PLoS computational biology. 17 [PubMed]