HH model of SCN neurons including a transient K+ channel (Bano-Otalora et al 2021)

This MATLAB code is associated with the paper "Daily electrical activity in the master circadian clock of a diurnal mammal" by Beatriz Bano-Otalora, Matthew J Moye, Timothy Brown, Robert J Lucas, Casey O Diekman, Mino DC Belle. eLife 2021; 10:e68719 DOI: https://doi.org/10.7554/eLife.68179 It simulates a Hodgkin-Huxley-type model of the electrical activity of suprachiasmatic nucleus (SCN) neurons in the diurnal rodent Rhabdomys pumilio. Model parameters were inferred from current-clamp recordings using data assimilation (DA) algorithms available at https://github.com/mattmoye/neuroDA

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Suprachiasmatic nucleus (SCN) neuron

Currents: I A; I Calcium; I Na,t; I K; I h; I K,leak; I Na, leak

Model Concept(s): Action Potentials; Circadian Rhythms; Depolarization block; Parameter Fitting

Simulation Environment: MATLAB

Implementer(s): Diekman, Casey O. [casey.o.diekman at njit.edu]; Moye, Matthew; Saghafi, Soheil


Bano-Otalora B et al. (2021). Daily electrical activity in the master circadian clock of a diurnal mammal eLife.

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