Activity-dependent broadening of axonal spikes by inactivating K channels (Zheng & Kamiya 2023)


"Simulation of use-dependent changes in axonal K and Ca currents during action potentials propagating along hippocampal mossy fibers. The model resembling inactivating axonal K current caused a broadening of action potentials, while replacement with a non-inactivating model abolished the use-dependent changes." Reference: 1. Zheng F, Kamiya H (2023) Simulation test for impartment of use-dependent plasticity by inactivation of axonal potassium channels on hippocampal mossy fibers. Front Cell Neurosci doi: 10.3389/fncel.2023.1154910

Model Type: Axon

Region(s) or Organism(s): Hippocampus

Cell Type(s): Dentate gyrus granule GLU cell

Currents: I K; I N; I Na,t; I p,q; I R

Model Concept(s): Action Potentials; Axonal Action Potentials; Analog coding

Simulation Environment: NEURON

Implementer(s): Kamiya, Haruyuki [kamiya at med.hokudai.ac.jp]

References:

Zheng F, Kamiya H. (). Simulation test for impartment of use-dependent plasticity by inactivation of axonal potassium channels on hippocampal mossy fibers. Front Cell Neurosci.


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