"Simulation of use-dependent changes in axonal K and Ca currents during action potentials propagating along hippocampal mossy fibers. The model resembling inactivating axonal K current caused a broadening of action potentials, while replacement with a non-inactivating model abolished the use-dependent changes." Reference: 1. Zheng F, Kamiya H (2023) Simulation test for impartment of use-dependent plasticity by inactivation of axonal potassium channels on hippocampal mossy fibers. Front Cell Neurosci doi: 10.3389/fncel.2023.1154910
Model Type: Axon
Region(s) or Organism(s): Hippocampus
Cell Type(s): Dentate gyrus granule GLU cell
Currents: I K; I N; I Na,t; I p,q; I R
Model Concept(s): Action Potentials; Axonal Action Potentials; Analog coding
Simulation Environment: NEURON
Implementer(s): Kamiya, Haruyuki [kamiya at med.hokudai.ac.j]
References:
Zheng F, Kamiya H. (). Simulation test for impartment of use-dependent plasticity by inactivation of axonal potassium channels on hippocampal mossy fibers. Front Cell Neurosci.