CA1 pyr cell: phenomenological NMDAR-based model of synaptic plasticity (Dainauskas et al 2023)

This Python code implements a phenomenological NMDA receptor-based voltage-dependent model of synaptic plasticity for CA3-CA1 synapse and shows weight changes of a synapse placed on a two-compartmental model of a hippocampal CA1 pyramidal neuron for spike-timing-dependent synaptic plasticity (STDP) and frequency-dependent synaptic plasticity stimulation protocols. The developed model predicts altered learning rules in synapses formed on the apical dendrites of the detailed compartmental model of CA1 pyramidal neuron in the presence of the GluN2B-NMDA receptor hypofunction.

Model Type: Neuron or other electrically excitable cell; Synapse

Region(s) or Organism(s): Hippocampus

Cell Type(s): Hippocampus CA1 pyramidal GLU cell

Receptors: AMPA; NMDA

Transmitters: Glutamate

Model Concept(s): STDP; Synaptic Plasticity

Simulation Environment: Python


Dainauskas JJ, Marie H, Migliore M, Saudargiene A. (2023). GluN2B-NMDAR subunit contribution on synaptic plasticity: a phenomenological model for CA3-CA1 synapses Frontiers in Synaptic Neuroscience. 15

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