Single neuron models of four types of L1 mouse Interneurons: Canpy, NGFC, alpha7 and VIP cells

Neocortical Layer 1 (L1) consists of the distal dendrites of pyramidal cells and GABAergic interneurons (INs) and receives extensive long-range “top-down” projections, but L1 INs remain poorly understood. In this work, we systematically examined the distinct dominant electrophysiological features for four unique IN subtypes in L1 that were previously identified from mice of either gender: Canopy cells show an irregular firing pattern near rheobase; Neurogliaform cells (NGFCs) are late-spiking, and their firing rate accelerates during current injections; cells with strong expression of the a7 nicotinic receptor (a7 cells), display onset (rebound) bursting; vasoactive intestinal peptide (VIP) expressing cells exhibit high input resistance, strong adaptation, and irregular firing. Computational modeling revealed that these diverse neurophysiological features could be explained by an extended exponential-integrate-and-fire neuron model with varying contributions of a slowly inactivating K+ channel (SIK), a T-type Ca2+ channel, and a spike-triggered Ca2+-dependent K+ channel. In particular, we show that irregular firing results from square-wave bursting through a fast-slow analysis. Furthermore, we demonstrate that irregular firing is frequently observed in VIP cells due to the interaction between strong adaptation and a SIK channel. At last, we reveal that the VIP and a7 cell models resonant with Alpha/Theta band input through a dynamic gain analysis.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Abstract integrate-and-fire leaky neuron

Currents: I K,Ca; I T low threshold; I K

Simulation Environment: Brian 2


Meng JH, Schuman B, Rudy B, Wang XJ. (). Mechanisms of Dominant Electrophysiological Features of Four Subtypes of Layer 1 Interneurons J Neuroscience.

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