Glial voltage dynamics driven by Kir & K2P currents (Janjic et al 2023)

The almost linear current-voltage relationship of most glial membranes results from multiple non-linear potassium leaky-pore or background conductances. The corresponding channel types develop and deregulate independently, some of them asymmetrically – producing non-monotonic I-V curves. The consequences of those alterations on whole-cell voltage responses have not been explored. We developed a minimal ordinary differential equation model of voltage dynamics incorporating detailed models of the different potassium currents based on electrophysiological recordings. Parametrically inducing some of the reported changes in rectification of glial Kir currents resulted in instability of the nominal resting membrane potential and the appearance of a second, much more depolarized resting state. If prolonged glial depolarizations prove plausible such bistability would change the present understanding of glial Vm dynamics.

Model Type: Glia

Region(s) or Organism(s): Hippocampus

Cell Type(s): Astrocyte

Currents: Kir; I Potassium

Model Concept(s): Bifurcation; Detailed Neuronal Models

Simulation Environment: XPPAUT

Implementer(s): Janjic, Predrag; Solev, Dimitar


Janjic P, Solev D, Kocarev L. (2023). Non-trivial dynamics in a model of glial membrane voltage driven by open potassium pores Biophysical journal. 122 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.