We showed that DC axons are activated synchronously during c-SCS (50 Hz) and asynchronously during kf-SCS. Through experiments and computational simulations, we explained the basis for and consequences of desynchronization, showing that asynchronous spikes are sufficient to mediate pain relief whereas synchronous spikes are necessary for paresthesia.
Model Type: Neuron or other electrically excitable cell
Model Concept(s): Synchronization
Simulation Environment: NEURON; Python; MATLAB
Implementer(s): Zhang, Tianhe [tz5@duke.edu]; Abdollahi, Nooshin [nooshin.abdollahi at mail.utoronto.ca]; Medlock, Laura [laura.medlock at mail.utoronto.ca]
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