Role of synchrony in sensation and the basis for paresthesia-free spinal cord stimulation

We showed that DC axons are activated synchronously during c-SCS (50 Hz) and asynchronously during kf-SCS. Through experiments and computational simulations, we explained the basis for and consequences of desynchronization, showing that asynchronous spikes are sufficient to mediate pain relief whereas synchronous spikes are necessary for paresthesia.

Model Type: Neuron or other electrically excitable cell

Model Concept(s): Synchronization

Simulation Environment: NEURON; Python; MATLAB

Implementer(s): Zhang, Tianhe []; Abdollahi, Nooshin [nooshin.abdollahi at]; Medlock, Laura [laura.medlock at]


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