Boundary effects influence velocity in transverse propagation of cardiac APs (Sperelakis et al 2005)

... earlier experiments were carried out with 2-dimensional sheets of cells: 2 × 3, 3 × 4, and 5 × 5 models (where the first number is the number of parallel chains and the second is the number of cells in each chain). The purpose of the present study was to enlarge the model size to 7 × 7, thus enabling the transverse velocities to be compared in models of different sizes (where all circuit parameters are identical in all models). This procedure should enable the significance of the role of edge (boundary) effects in transverse propagation to be determined. See paper for more and details.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Heart cell

Currents: I Sodium; I Calcium; I Potassium

Model Concept(s): Activity Patterns; Action Potentials

Simulation Environment: PSpice

References:

Sperelakis N, Kalloor B, Ramasamy L. (2005). Boundary effects influence velocity of transverse propagation of simulated cardiac action potentials. Theoretical biology & medical modelling. 2 [PubMed]