HERG K+ channels spike-frequency adaptation (Chiesa et al 1997)

Spike frequency adaptation has contributions from the IHERG current (encoded by the human eag-related gene (HERG); Warmke & Ganetzky, 1994), which develops with slow kinetics during depolarization and contributes to the repolarization of the long action potentials typically present in the heart. IHERG is one of the delayed rectifier currents (IK(r)) of the heart, and HERG mutations are associated with one of the cardiac arrhythmia LQT syndromes (LQT2). See paper for more and details.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Neuroblastoma

Currents: I_HERG

Model Concept(s): Action Potentials; Long-QT; Spike Frequency Adaptation

Simulation Environment: XPPAUT

Implementer(s): Wu, Sheng-Nan [snwu at mail.ncku.edu.tw]; Chang, Han-Dong; Wu, Jiun-Shian [coolneon at gmail.com]


Chiesa N, Rosati B, Arcangeli A, Olivotto M, Wanke E. (1997). A novel role for HERG K+ channels: spike-frequency adaptation. The Journal of physiology. 501 ( Pt 2) [PubMed]

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