Spike frequency adaptation has contributions from the IHERG current (encoded by the human eag-related gene (HERG); Warmke & Ganetzky, 1994), which develops with slow kinetics during depolarization and contributes to the repolarization of the long action potentials typically present in the heart. IHERG is one of the delayed rectifier currents (IK(r)) of the heart, and HERG mutations are associated with one of the cardiac arrhythmia LQT syndromes (LQT2). See paper for more and details.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Neuroblastoma
Currents: I_HERG
Model Concept(s): Action Potentials; Long-QT; Spike Frequency Adaptation
Simulation Environment: XPPAUT
Implementer(s): Wu, Sheng-Nan [snwu at mail.ncku.edu.tw]; Chang, Han-Dong; Wu, Jiun-Shian [coolneon at gmail.com]
References:
Chiesa N, Rosati B, Arcangeli A, Olivotto M, Wanke E. (1997). A novel role for HERG K+ channels: spike-frequency adaptation. The Journal of physiology. 501 ( Pt 2) [PubMed]