Dendritic Na inactivation drives a decrease in ISI (Fernandez et al 2005)

We use a combination of dynamical analysis and electrophysiological recordings to demonstrate that spike broadening in dendrites is primarily caused by a cumulative inactivation of dendritic Na(+) current. We further show that a reduction in dendritic Na(+) current increases excitability by decreasing the interspike interval (ISI) and promoting burst firing.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): ELL pyramidal cell

Currents: I Na,t; I K

Model Concept(s): Activity Patterns; Dendritic Action Potentials; Active Dendrites

Simulation Environment: MATLAB

Implementer(s): Fernandez FR [ffernand at]; Mehaffey WH


Fernandez FR, Mehaffey WH, Turner RW. (2005). Dendritic Na+ current inactivation can increase cell excitability by delaying a somatic depolarizing afterpotential. Journal of neurophysiology. 94 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.