CA1 Pyramidal Neuron: Synaptic Scaling (London, Segev 2001)

London and Segev (2001) discuss location dependent and location independent synaptic scaling in a model CA1 neuron with passive dendrites. The freely available text is followed by a critique by Maggee and Cook who comment that the London and Segev model is accurate and informative and however needs to be augmented by active channels in dendrites. Note: the zip files for this model are stored at the nature neuroscience website - Click above Supplementary Source Code in the readme.html in the model files

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Hippocampus CA1 pyramidal GLU cell

Receptors: AMPA

Model Concept(s): Activity Patterns; Simplified Models; Influence of Dendritic Geometry

Simulation Environment: NEURON (web link to model)

Implementer(s): London, Mickey [MikiLon at lobster.ls.huji.ac.il]

References:

London M, Segev I. (2001). Synaptic scaling in vitro and in vivo. Nature neuroscience. 4 [PubMed]