CA1 pyramidal neuron: Synaptic Scaling (Magee, Cook 2000)

Jeffrey Magee and Erik Cook found evidence in experiments and modeling that support the hypothesis that an increase in synaptic conductance for synapses at larger distances from the soma is responsible for reducing the location dependence (relative to the soma) of synapses.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Hippocampus CA1 pyramidal GLU cell

Receptors: AMPA

Model Concept(s): Influence of Dendritic Geometry

Simulation Environment: NEURON

Implementer(s): Magee, Jeffrey [jmagee at]


Magee JC, Cook EP. (2000). Somatic EPSP amplitude is independent of synapse location in hippocampal pyramidal neurons. Nature neuroscience. 3 [PubMed]

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