Input Fluctuations effects on f-I curves (Arsiero et al. 2007)


"... We examined in vitro frequency versus current (f-I) relationships of layer 5 (L5) pyramidal cells of the rat medial prefrontal cortex (mPFC) using fluctuating stimuli. ...our results show that mPFC L5 pyramidal neurons retain an increased sensitivity to input fluctuations, whereas their sensitivity to the input mean diminishes to near zero. This implies that the discharge properties of L5 mPFC neurons are well suited to encode input fluctuations rather than input mean in their firing rates, with important consequences for information processing and stability of persistent activity at the network level."

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Prefrontal cortex (PFC)

Cell Type(s): Neocortex L5/6 pyramidal GLU cell

Currents: I Sodium; I Potassium

Model Concept(s): Simplified Models; Action Potentials; Spike Frequency Adaptation

Simulation Environment: NEURON

References:

Arsiero M, L├╝scher HR, Lundstrom BN, Giugliano M. (2007). The impact of input fluctuations on the frequency-current relationships of layer 5 pyramidal neurons in the rat medial prefrontal cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27 [PubMed]


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