"Intracellular recordings of neuronal membrane potential are a central tool in neurophysiology. ... We introduce a computer-aided technique, Active Electrode Compensation (AEC), based on a digital model of the electrode interfaced in real time with the electrophysiological setup. ... AEC should be particularly useful to characterize fast neuronal phenomena intracellularly in vivo."
Model Concept(s): Methods
Simulation Environment: NEURON (web link to model); MATLAB (web link to model); Python (web link to model); Scilab (web link to model)
Implementer(s): Brette R
References:
Brette R et al. (2008). High-resolution intracellular recordings using a real-time computational model of the electrode. Neuron. 59 [PubMed]