Biophysical and phenomenological models of spike-timing dependent plasticity (Badoual et al. 2006)

"Spike-timing dependent plasticity (STDP) is a form of associative synaptic modification which depends on the respective timing of pre- and post-synaptic spikes. The biophysical mechanisms underlying this form of plasticity are currently not known. We present here a biophysical model which captures the characteristics of STDP, such as its frequency dependency, and the effects of spike pair or spike triplet interactions. ... A simplified phenomenological model is also derived..."

Model Type: Neuron or other electrically excitable cell

Currents: I Na,t; I K; I M; I Calcium

Receptors: AMPA; NMDA

Model Concept(s): Simplified Models; Synaptic Plasticity; Long-term Synaptic Plasticity; STDP

Simulation Environment: NEURON

References:

Badoual M et al. (2006). Biophysical and phenomenological models of multiple spike interactions in spike-timing dependent plasticity. International journal of neural systems. 16 [PubMed]