Roles of I(A) and morphology in AP prop. in CA1 pyramidal cell dendrites (Acker and White 2007)

" ...Using conductance-based models of CA1 pyramidal cells, we show that underlying “traveling wave attractors” control action potential propagation in the apical dendrites. By computing these attractors, we dissect and quantify the effects of IA channels and dendritic morphology on bAP amplitudes. We find that non-uniform activation properties of IA can lead to backpropagation failure similar to that observed experimentally in these cells. ... "

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Hippocampus

Cell Type(s): Hippocampus CA1 pyramidal GLU cell

Currents: I Na,t; I A; I K

Model Concept(s): Active Dendrites; Influence of Dendritic Geometry; Action Potentials

Simulation Environment: XPPAUT

Implementer(s): Acker, Corey [acker at uchc.edu]

References:

Acker CD, White JA. (2007). Roles of IA and morphology in action potential propagation in CA1 pyramidal cell dendrites. Journal of computational neuroscience. 23 [PubMed]