"To better understand the direct effects of DBS (Deep brain stimulation) on central neurons, a computational model of a myelinated axon has been constructed which includes the effects of K+ accumulation within the peri-axonal space. Using best estimates of anatomic and electrogenic model parameters for in vivo STN axons, the model predicts a functional block along the axon due to K+ accumulation in the submyelin space. ... These results suggest that therapeutic DBS of the STN likely results in a functional block for many STN axons, although a subset of STN axons may also be activated at the stimulating frequency. "
Model Type: Axon
Cell Type(s): Subthalamus nucleus projection neuron
Currents: I Na,p; I K; I Sodium; I_Ks; Na/K pump
Model Concept(s): Axonal Action Potentials; Action Potentials; Deep brain stimulation; Sodium pump; Depolarization block
Simulation Environment: NEURON
Implementer(s): Bellinger, Steven [Steve.Bellinger at asu.edu]
References:
Bellinger SC, Miyazawa G, Steinmetz PN. (2008). Submyelin potassium accumulation may functionally block subsets of local axons during deep brain stimulation: a modeling study. Journal of neural engineering. 5 [PubMed]