" ... In numerical simulations, the availability of both Na+ and A-type K+ channels during autonomous firing were reduced when SK channels were removed, and a nearly equal reduction in Na+ and K+ subthreshold-activated ion channel availability produced a large decrease in the neuron's slope conductance near threshold. This change made the neuron more sensitive to intrinsically generated noise. In vivo, this change would also enhance the sensitivity of GP (Globus Pallidus) neurons to small synaptic inputs."
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Globus pallidus neuron
Currents: I Na,p; I Na,t; I A; I K; I K,Ca; I Sodium; I Potassium
Model Concept(s): Oscillations; Noise Sensitivity
Simulation Environment: NEURON
Implementer(s): Deister, Christopher [chris.deister at utsa.edu]
References:
Deister CA, Chan CS, Surmeier DJ, Wilson CJ. (2009). Calcium-activated SK channels influence voltage-gated ion channels to determine the precision of firing in globus pallidus neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29 [PubMed]