"The model is for a generic, single compartment neuron with multiple ion currents. The most notable mechanisms include ClC-2 (a rectifying chloride-leak channel) and KCC2 (potassium chloride co-transporter 2). A significant feature of the model is that it tracks intracellular chloride concentration. Moreover, the GABA-A receptor is modeled as passing both chloride and bicarbonate ions, which is important for proper calculation of the GABA reversal potential. Ornstein-Unlenbeck processes to simulate synaptic inhibition and excitation are also included."
Model Type: Neuron or other electrically excitable cell
Currents: I Cl, leak
Genes: CLC-2 CLCN2
Model Concept(s): Chloride regulation
Simulation Environment: XPPAUT
Implementer(s): Prescott, Steven [steve.prescott at sickkids.ca]]
References:
Ratté S, Prescott SA. (2011). ClC-2 channels regulate neuronal excitability, not intracellular chloride levels. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31 [PubMed]