Spike repolarization in axon collaterals (Foust et al. 2011)

Voltage sensing dye experiments and simulations characterize the location and re-polarizing function of Kv1 channels in cortical neurons. "... (the papers) results indicate that action potential-induced synaptic transmission may operate through a mix of analog–digital transmission owing to the properties of Kv1 channels in axon collaterals and presynaptic boutons."

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell

Currents: I Na,t; I K; I_KD

Model Concept(s): Action Potentials

Simulation Environment: NEURON

References:

Foust AJ, Yu Y, Popovic M, Zecevic D, McCormick DA. (2011). Somatic membrane potential and Kv1 channels control spike repolarization in cortical axon collaterals and presynaptic boutons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31 [PubMed]