Modeling conductivity profiles in the deep neocortical pyramidal neuron (Wang K et al. 2013)

"With the rapid increase in the number of technologies aimed at observing electric activity inside the brain, scientists have felt the urge to create proper links between intracellular- and extracellular-based experimental approaches. Biophysical models at both physical scales have been formalized under assumptions that impede the creation of such links. In this work, we address this issue by proposing amulticompartment model that allows the introduction of complex extracellular and intracellular resistivity profiles. This model accounts for the geometrical and electrotonic properties of any type of neuron through the combination of four devices: the integrator, the propagator, the 3D connector, and the collector. ..."

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Neocortex L5/6 pyramidal GLU cell

Currents: I Na,t; I K; I h; I_Ks

Model Concept(s): Dendritic Action Potentials; Influence of Dendritic Geometry; Extracellular Fields; Evoked LFP; Conductance distributions

Simulation Environment: NEURON (web link to model); MATLAB (web link to model)


Wang K, Riera J, Enjieu-Kadji H, Kawashima R. (2013). The role of extracellular conductivity profiles in compartmental models for neurons: particulars for layer 5 pyramidal cells. Neural computation 25 [PubMed]