"... Previous work showed that magnetic electrical field-induced antinoceptive action is mediated by activation of capsaicin-sensitive sensory afferents. In this study, a modified Hodgkin-Huxley model, in which TRP-like current (I-TRP) was incorporated, was implemented to predict the firing behavior of action potentials (APs), as the model neuron was exposed to sinusoidal changes in externally-applied voltage. ... Our simulation results suggest that modulation of TRP-like channels functionally expressed in small-diameter peripheral sensory neurons should be an important mechanism through which it can contribute to the firing pattern of APs."
Model Type: Axon
Cell Type(s): Squid axon
Model Concept(s): Action Potentials
Simulation Environment: R
Implementer(s): Wu, Sheng-Nan [snwu at mail.ncku.edu.tw]; Huang, Chin-Wei; Chen, Bing-Shuo
References:
HODGKIN AL, HUXLEY AF. (1952). A quantitative description of membrane current and its application to conduction and excitation in nerve. The Journal of physiology 117 [PubMed]
Chen BS, Lo YC, Lius YC, Wu SN. (2010). Effects of transient receptor potential-like current on the firing pattern of action potentials in the Hodgkin-Huxley neuron during exposure to sinusoidal external voltage. The Chinese journal of physiology 53 [PubMed]