Multi-comp. CA1 O-LM interneuron model with varying dendritic Ih distributions (Sekulic et al 2015)

The model presented here was used to investigate possible dendritic distributions of the HCN channel-mediated current (Ih) in models of oriens-lacunosum/moleculare (O-LM) CA1 hippocampal interneurons. Physiological effects of varying the dendritic distributions consisted of examining back-propagating action potential speeds.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Hippocampus CA1 stratum oriens lacunosum-moleculare interneuron

Currents: I Na,t; I A; I K; I K,leak; I M; I h; I K,Ca; I Calcium; I_AHP

Model Concept(s): Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models; Conductance distributions

Simulation Environment: NEURON

References:

Sekulić V, Chen TC, Lawrence JJ, Skinner FK. (2015). Dendritic distributions of I h channels in experimentally-derived multi-compartment models of oriens-lacunosum/moleculare (O-LM) hippocampal interneurons. Frontiers in synaptic neuroscience. 7 [PubMed]