Signaling pathways underlying LTP in hippocampal CA1 pyramidal cells (Jedrzejewska-Szmek et al 2017)

" ...We investigated whether the diverse experimental evidence can be unified by creating a spatial, mechanistic model of multiple signaling pathways in hippocampal CA1 neurons. Our results show that the combination of activity of several key kinases can predict the occurrence of long-lasting forms of LTP for multiple experimental protocols. ..."

Model Type: Synapse

Cell Type(s): Hippocampus CA1 pyramidal GLU cell

Transmitters: Ephinephrine

Model Concept(s): Long-term Synaptic Plasticity; Signaling pathways

Simulation Environment: NeuroRD

Implementer(s): Blackwell, Avrama [avrama at gmu.edu]; Jedrzejewska-Szmek, Joanna

References:

Jȩdrzejewska-Szmek J, Luczak V, Abel T, Blackwell KT. (2017). ß-adrenergic signaling broadly contributes to LTP induction. PLoS computational biology. 13 [PubMed]