Axonal ectopic burst induced by repetitive stimuli of hippocampal mossy fiber

Simulation of ectopic burst firings from distal axons induced by repetitive stimuli of the hippocampal mossy fibers.

Experimental motivation: To test for possible ectopic spiking at the distal axon by repetitive stimulation, a well-known condition causing hyperexcitability of the hippocampal network.

Model Type: Axon

Region(s) or Organism(s): Hippocampus

Cell Type(s): Dentate gyrus granule GLU cell

Currents: I K; I Na,t

Receptors:

Genes:

Transmitters:

Model Concept(s): Action Potentials; Axonal Action Potentials; Excitability

Simulation Environment: NEURON

References: