A PV+ interneuron model in the netpyne environment with code to test SCN1A variant effects on rheobase and depolarization block threshold.
Model Type:
Region(s) or Organism(s):
Cell Type(s):
Currents: I Sodium
Receptors:
Genes: Nav1.1 SCN1A
Transmitters:
Model Concept(s): Epilepsy
Simulation Environment: NetPyNE
References:
Knox AT et al. (2025). Genotype-function-phenotype correlations for SCN1A variants identified by clinical genetic testing. Annals of clinical and translational neurology. 12 [PubMed]