" ... Computer simulations confirmed that pharmacological enhancement of KCNQ/Kv7 channel (M current) activity decreases excitability and also suggested that the effects of inhibition of KCNQ/Kv7 channels on the excitability of spinal MNs do not depend on a direct effect in these neurons but likely on spinal cord synaptic partners. These results indicate that KCNQ/Kv7 channels have a fundamental role in the modulation of the excitability of spinal MNs acting both in these neurons and in their local presynaptic partners. ..."
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Spinal motoneuron
Cell Type(s): Spinal cord lumbar motor neuron alpha ACh cell
Currents: I Potassium; I K; I Na,t; I M
Model Concept(s): Axonal Action Potentials
Simulation Environment: NEURON
Implementer(s): Lombardo, Joseph [josslomb at gmail.com]
References:
Lombardo J, Harrington MA. (2016). Nonreciprocal mechanisms in up- and downregulation of spinal motoneuron excitability by modulators of KCNQ/Kv7 channels. Journal of neurophysiology. 116 [PubMed]